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| Certification: | BRC, ISO, FDA, HACCP, Kosher,Halal |
| Assay Method: | HPLC, UV |
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Product Name:Melatonin/ Melatonin extract/Melatonin powder
Molecular Formula: C13H16N2O2
Molecular Weight: 232.28
Appearance: White crystalline fine powder
CAS NO.: 73-31-4
Specification: Melatonin 99% HPLC
What is Melatonin?
Melatonin is an indolamine that is produced in the pineal gland. Its chemical appellation is N-Acetyl-5-Methoxytryptamine or C13-H16-N2-O2.
The pineal gland is a pea sized entity located near the base of the brain. It has a regulatory effect on the hypothalamus gland and influences the functioning of the thyroid,thymus,pancreas and adrenal glands.
What is the function of Melatonin?
1.Helps regulate other hormones and maintain the body's circadian rhythm. 2. Melatonin also helps control the timing
3. Melatonin helps determine
4. Melatonin has strong antioxidant effects.
5. Release of female reproductive hormones.
Research conducted over the past two decades confirm that melatonin has anti-oxidant,immuno protective and sleep regulating properties. It may also prove to be effective as a prophylaxis against osteoporosis and a possible new adjunction in the fight against cancer.
Melatonin produces a substances called arginine vasotocin. This secretion has an inhibiting effect upon cortisol, a stress hormone produced by the adrenal glands. Insomniacs typically tend to have high nighttime levels of the hormone which tends to keep them in an agitated state. inhibition of this hormone promotes sleep and allows time for regeneration.
The metabolic pathway by which melatonin is produced, involves a by product of tryptophan called serotonin. When you consider that tryptophan is the least abundant of the essential amino acids in the normal diet, there is a greater likelihood of a melatonin shortfall because the compound it's produced from, serotonin, would also be reduced.
Describe its anti-oxidant capabilities.
Many disease are directly related to free radicals(molecules with unpaired electrons) that can cause cellular damage. A list, to name a few, would include atherosclerosis, emphysema, muscular dystrophy, and cataracts. Among the free radicals produced, the hydroxyl(.OH) oxygen vitro testing have demonstrated that melatonin is four times more effective than glutathione, an important free radical fighter, in scavenging the reactive. In vivo tests in animals utilizing safrole (a potent carcinogen from sassefras oil) demonstrated a significant reduction in damaged hepatic DNA when compared to those who were not pre-treated with melatonin - 99% when administered at a level of 4mg/Kg (reiter et al., 1994). Similarly, an in vitro system used by (tran et al., 1993) showed that hydrogen peroxide exposed to ultra violet light and reacted with melatonin would form six times as less hydroxyl radicals than with glutathione.
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