| Customization: | Available |
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| Certification: | BRC, ISO, cGMP, Halal, Kosher |
| Assay Method: | HPLC |
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INTRODUCTION:
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).
Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.
FUNTION:
1. Increases blood flow.
2. Increases the rate at which brain cells produce ATP (which is a cell molecule that creates energy).
3. Speeds up the use of glucose in the brain. Regulates Sodium/ Potassium channels.
4. Speeds up the use of oxygen in the brain.
5. Vinpocetine increases levels of neurotransmitters involved in memory.
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