Botanica Rootstock Extract 98% Podophyllotoxin

• Certification: RoHS, BRC, ISO, FDA, HACCP
• Assay Method: HPLC
• Application Form: Injection, Lotion, Suppository, Paste, Tablet, Capsule
• Application: Food, Health Care Products, Medicine
• State: Powder
• Transport Package: 20kg/Drum
• Model NO.: Podophyllotoxin
• Specification: 95%, 98%, 99%Podophyllotoxin
• Trademark: Hunan Nutramax
• Origin: China
• HS Code: 1302199099
• Production Capacity: 3-5mt/Month

Product Description

Botanica Rootstock Extract 98% Podophyllotoxin 

Product Description

Podophyllotoxin 

 

 

• English name: Podophyllotoxin
• Latin name: Podophyllotoxin Tincture
• Active ingredients: Podophyllotoxin
• Origin: Rootstock
• Specification: 95%,98% ,99%Podophyllotoxin
• Appearance: White Powder
• CAS#: 518-28-5
• Molecular formula: C22H22O8
• Molecular Weight: 414.40
• Extract Method:Grain alcohol
• Test Method:HPLC

 

Introduction

-Usages and applications:
 

Podophyllotoxin displays a range of activities such as cathartic, purgative, antiviral, vesicant, and antihelminthic. Additionally, the lignan and its derivatives are exciting leads for anti-tumor agent. For instance, podophyllotoxin is the pharmacological precursor for the important anticancer drug etoposide.
It is also used as a gel or solution to treat genital warts with noticeably shorter duration and fewer side effects.
 

-Mechanism of action:

Podophyllotoxin's anticancer property can be attributed to the inhibition of tubulin polymerization. As podophyllotoxin binds to the tubulin, microtubule formation is prevented. Consequently, podophyllotoxin arrests the cell cycle in the metaphase.
 
Podophyllotoxin derivatives display binding activity to the enzyme topoisomerase II during the late S and early G2 stage. For instance, etoposide binds and stabilizes the temporary break caused by the enzyme, disrupts the reparation of the break through which the double-stranded DNA passes, and consequently stops DNA unwinding and replication.Mutants resistant to either podophyllotoxin, or to its topoisomerase II inhibitory derivatives such as etoposide (VP-16), have been described in Chinese hamster cells.The mutually exclusive cross-resistance patterns of these mutants provide a highly specific mean to distinguish the two kinds of podophyllotoxin derivatives.Mutant Chinese hamster cells resistant to podophyllotoxin are affected in a protein P1 that was later identified as the mammalian HSP60 or chaperonin protein.

 

Packaging & Shipping

 

Packing:

• Delivery Time: Around 3-5 workdays after your payment.
• Package: In fiber-drums with two-plastic bags inside.
• Net Weight: 25kgs/Drum / Gross Weight: 28kgs/Drum
• Drum Size & Volume: I.D.42cm × H52cm, 0.08 m³/ Drum
• Storage: Stored in dry and cool place, keep away from strong light and heat
• Shelf Life: Two years when properly stored.

Shipping:

• DHL Express, FEDEX and EMS for quantity less than 50KG, usually called as DDU service;
• Sea shipping for quantity over 500KG; and air shipping is available for 50KG above;
• For high value products, please select air shipping and DHL express for safe;
• Please confirm if you can make the clearance when goods reach your customs before placing an order, for buyers from Mexico, Turkey, Italy, Romania,Russia, and other remote area.

Company Profile

 

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